Carmacks is a village in the Yukon on the Yukon River along the Klondike Highway, and at the west end of the Robert Campbell Highway from Watson Lake.

The population is 426 (Yukon Bureau of Statistics, June 2007). It is the home of the Little Salmon/Carmacks First Nation, a Northern Tutchone-speaking people.

Carmacks is situated at the confluence of the Nordenskiold and Yukon Rivers, approximately 180 km north of Whitehorse and 360 km south of Dawson City on the North Klondike Highway.

It is the site of one of the four bridges over the Yukon River. The Campbell Highway also intersects the community and carries on to Faro, Ross River and Watson Lake, providing a gateway to the Canol Road and some of the Yukon's most spectacular scenery.